Formulation and Evaluation of Transdermal Patch of Repaglinide
نویسندگان
چکیده
منابع مشابه
Formulation and Evaluation of Transdermal Patch of Repaglinide
Repaglinide has the half life of 1 hour, and bioavailability in the body is 56% due to first-pass metabolism. The total daily dose of Repaglinide is 16 mg (e.g., 4 mg four times daily depending on meal patterns); hence, it required frequent dosing. Transdermal patch of Repaglinide was prepared to sustain the release and improve bioavailability of drug and patient compliance. Different formulati...
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The present investigation involves formulation and evaluation of microspheres with Repaglinide as model drug for prolongation of drug release time. An attempt was made to prepare microspheres of Repaglinide by Quasi emulsion solvent diffusion technique, with a view to deliver the drug at sustained or controlled manner in gastrointestinal tract and consequently into systemic circulation. The mic...
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ژورنال
عنوان ژورنال: ISRN Pharmaceutics
سال: 2011
ISSN: 2090-6145,2090-6153
DOI: 10.5402/2011/651909